منابع مشابه
Para-aminobenzoic Acid Production by Staphylococci
1. Strains of staphylococci produce diazotizable materials which can be converted to a dye, and the intensity of the color reaction can be quantitated in the same manner as p-aminobenzoic acid. The sulfonamide-resistant strains which we have studied produce more diazotizable substance than non-resistant strains. 2. The development of a color by the diazotizable substance can be inhibited by exp...
متن کاملpara-Aminobenzoic acid is a precursor in coenzyme Q6 biosynthesis in Saccharomyces cerevisiae.
Coenzyme Q (ubiquinone or Q) is a crucial mitochondrial lipid required for respiratory electron transport in eukaryotes. 4-Hydroxybenozoate (4HB) is an aromatic ring precursor that forms the benzoquinone ring of Q and is used extensively to examine Q biosynthesis. However, the direct precursor compounds and enzymatic steps for synthesis of 4HB in yeast are unknown. Here we show that para-aminob...
متن کاملThe replacement of para-aminobenzoic acid by methionine in the growth of a Neurospora mutant.
Present knowledge of the function of para-aminobenzoic acid (PABA) has been derived almost exclusively from sulfanilamide (SAN) inhibition studies. Shive and Roberts (1946) have advanced the hypothesis that PABA is catalytically active in the synthesis of a number of metabolic products in Escherichia coli and that the enzyme systems concerned in their production are differentially sensitive to ...
متن کاملAntidyspnoeic action of para-aminobenzoic acid: modifications of the functional respiratory indexes in the patients treated.
Benda and Poirot,1 in 1945, in order to avoid the secondary reactions provoked by intravenous injections of procaine, which was recommended for the treatment of dyspnoea by Dos Ghali, Bourdin and Guiot,2 proposed using p-aminobenzoic acid (PAB) in the place of procaine. It is known that the latter, once in contact with the blood plasma transforms itself rapidly into p-aminobenzoic acid and diet...
متن کاملInvolvement of mitochondrial ferredoxin and para-aminobenzoic acid in yeast coenzyme Q biosynthesis.
Yeast ubiquinone or coenzyme Q(6) (Q(6)) is a redox active lipid that plays a crucial role in the mitochondrial electron transport chain. At least nine proteins (Coq1p-9p) participate in Q(6) biosynthesis from 4-hydroxybenzoate (4-HB). We now show that the mitochondrial ferredoxin Yah1p and the ferredoxin reductase Arh1p are required for Q(6) biosynthesis, probably for the first hydroxylation o...
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ژورنال
عنوان ژورنال: Nature
سال: 1949
ISSN: 0028-0836,1476-4687
DOI: 10.1038/163328a0